Heptral Ademetionine for Injection Pharmaceutical Products
Basic Info
Model No.: injection
Product Description
Model NO.: injection Certification: GMP Type: Chemical Reagent Ademetionine for Injection: Cirrhosis of The Liver Transport Package: 5 Vials+5 Ampoules/Box Function: Nutritional Therapeutics, Enzymes and Other Biochemical, Visceral System Medication, Cirrhosis of The Liver Grade Standard: Medicine Grade State: Injection Trademark: arrow and rex Specification: 500mg
1.Product name:Ademetionine for injection
2.Specification:500mg
3.Package:5 vials+5 ampoules/box
4.Shelf life:24 months
5.Registration dossiers are available.
If you are interested in our products, please feel free to contact us.
Composition, structure and packing
Lyophilisate for solution for IV and IM administration from almost white to white with a yellowish tint without inclusions; solvent - a clear, colorless to pale yellow, with no inclusions; reconstituted solution - Transparent, colorless to yellow color with no visible precipitate.
Solvent: L-lysine, Sodium hydroxide, Water for Injections.
Pharmacological action
Pharmacological action - hepatoprotective, anti-depressant, detoxifying, stimulating regeneration, antioxidant, neuroprotective.
Hepatoprotector has antidepressant activity. Has choleretic and cholekinetic action. Has detoxifying, regenerating, antioxidant, antifibrosing and neuroprotective properties.
Fills deficit ademetionine and stimulates its production in the body, is found in all environments of the body. The highest concentration of ademetionine noted in the liver and brain. Plays a key role in the metabolic processes of the body, is involved in important biochemical reactions: transmethylation, transsulfuration, transamination. In transmethylation reactions ademethionine sends a methyl group for the synthesis of cell membrane phospholipids, neurotransmitters, nucleic acids, proteins, hormones, and others. Transsulfation reactions of ademetionine ia a precursor of cysteine, taurine, glutathione (providing a redox mechanism cellular detoxification), acetylation coenzyme (involved in biochemical reactions of the citric acid cycle and replenishes the energy potential of the cell).
Increases of glutamine in the liver, cysteine and taurine in the plasma; reduces the amount of methionine in serum, normalizing the metabolic reaction in the liver. After decarboxylation involved in the process aminopropylation as precursor of polyamines - putrescine (stimulator of cell regeneration and proliferation of hepatocytes), spermidine, and spermine, within the structure of the ribosome, which reduces the risk of fibrosis.
Has choleretic action. Ademetionine normalizes endogenous synthesis of phosphatidylcholine in hepatocytes, which increases the fluidity and membrane polarization. This improves the function of membrane-associated hepatocyte transport systems of bile acids and facilitates passage of bile acids in the biliary system. Effective with intrahepatic (intralobular and interlobular) variant of cholestasis (impaired bile flow and synthesis). Ademetionine reduces the toxicity of bile acids in the hepatocyte, exercising their conjugation and sulfation. Conjugation with taurine increases the solubility of bile acids and removing them from the hepatocyte. The process of sulfation of bile acids contributes to the possibility of their elimination by the kidneys, facilitates the passage through the membrane of hepatocytes and excretion in the bile. Besides themselves sulfated bile acids also protect membranes of liver cells from the toxic action nonsulphated bile acids (present in high concentrations in hepatocytes in intrahepatic cholestasis). In patients with diffuse liver disease (cirrhosis, hepatitis) with intrahepatic cholestasis syndrome ademetionine reduces the severity of itching and changes in biochemical parameters, including the level of direct bilirubin, alkaline phosphatase activity, aminotransferases. Choleretic and hepatoprotective effect lasts up to 3 months after cessation of treatment.
The efficiency with hepatopathies caused by hepatotoxic drugs.
Appointment of patients with opioid addiction, accompanied by liver disease, leading to regression of clinical manifestations of withdrawal, improves the functional state of the liver and microsomal oxidation processes.
Antidepressant activity is manifested gradually, starting from the first week of treatment and stabilized for 2 weeks of treatment. The drug is effective in recurrent endogenous and neurotic depression that is resistant to amitriptyline. Has the ability to interrupt recurrences of depression.
Use of the drug in osteoarthritis reduces the severity of pain, increases the synthesis of proteoglycans and leads to partial regeneration of cartilage tissue.
Pharmacokinetics
Absorption
Bioavailability after parenteral injection - 96%, C max is reached in the plasma after 45 min.
Contact us if you need more details on Ademetionine for Injection. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Ademetionine、Pharmaceuticals. If these products fail to match your need, please contact us and we would like to provide relevant information.
1.Product name:Ademetionine for injection
2.Specification:500mg
3.Package:5 vials+5 ampoules/box
4.Shelf life:24 months
5.Registration dossiers are available.
If you are interested in our products, please feel free to contact us.
Composition, structure and packing
Lyophilisate for solution for IV and IM administration from almost white to white with a yellowish tint without inclusions; solvent - a clear, colorless to pale yellow, with no inclusions; reconstituted solution - Transparent, colorless to yellow color with no visible precipitate.
Solvent: L-lysine, Sodium hydroxide, Water for Injections.
Pharmacological action
Pharmacological action - hepatoprotective, anti-depressant, detoxifying, stimulating regeneration, antioxidant, neuroprotective.
Hepatoprotector has antidepressant activity. Has choleretic and cholekinetic action. Has detoxifying, regenerating, antioxidant, antifibrosing and neuroprotective properties.
Fills deficit ademetionine and stimulates its production in the body, is found in all environments of the body. The highest concentration of ademetionine noted in the liver and brain. Plays a key role in the metabolic processes of the body, is involved in important biochemical reactions: transmethylation, transsulfuration, transamination. In transmethylation reactions ademethionine sends a methyl group for the synthesis of cell membrane phospholipids, neurotransmitters, nucleic acids, proteins, hormones, and others. Transsulfation reactions of ademetionine ia a precursor of cysteine, taurine, glutathione (providing a redox mechanism cellular detoxification), acetylation coenzyme (involved in biochemical reactions of the citric acid cycle and replenishes the energy potential of the cell).
Increases of glutamine in the liver, cysteine and taurine in the plasma; reduces the amount of methionine in serum, normalizing the metabolic reaction in the liver. After decarboxylation involved in the process aminopropylation as precursor of polyamines - putrescine (stimulator of cell regeneration and proliferation of hepatocytes), spermidine, and spermine, within the structure of the ribosome, which reduces the risk of fibrosis.
Has choleretic action. Ademetionine normalizes endogenous synthesis of phosphatidylcholine in hepatocytes, which increases the fluidity and membrane polarization. This improves the function of membrane-associated hepatocyte transport systems of bile acids and facilitates passage of bile acids in the biliary system. Effective with intrahepatic (intralobular and interlobular) variant of cholestasis (impaired bile flow and synthesis). Ademetionine reduces the toxicity of bile acids in the hepatocyte, exercising their conjugation and sulfation. Conjugation with taurine increases the solubility of bile acids and removing them from the hepatocyte. The process of sulfation of bile acids contributes to the possibility of their elimination by the kidneys, facilitates the passage through the membrane of hepatocytes and excretion in the bile. Besides themselves sulfated bile acids also protect membranes of liver cells from the toxic action nonsulphated bile acids (present in high concentrations in hepatocytes in intrahepatic cholestasis). In patients with diffuse liver disease (cirrhosis, hepatitis) with intrahepatic cholestasis syndrome ademetionine reduces the severity of itching and changes in biochemical parameters, including the level of direct bilirubin, alkaline phosphatase activity, aminotransferases. Choleretic and hepatoprotective effect lasts up to 3 months after cessation of treatment.
The efficiency with hepatopathies caused by hepatotoxic drugs.
Appointment of patients with opioid addiction, accompanied by liver disease, leading to regression of clinical manifestations of withdrawal, improves the functional state of the liver and microsomal oxidation processes.
Antidepressant activity is manifested gradually, starting from the first week of treatment and stabilized for 2 weeks of treatment. The drug is effective in recurrent endogenous and neurotic depression that is resistant to amitriptyline. Has the ability to interrupt recurrences of depression.
Use of the drug in osteoarthritis reduces the severity of pain, increases the synthesis of proteoglycans and leads to partial regeneration of cartilage tissue.
Pharmacokinetics
Absorption
Bioavailability after parenteral injection - 96%, C max is reached in the plasma after 45 min.
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Contact us if you need more details on Ademetionine for Injection. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Ademetionine、Pharmaceuticals. If these products fail to match your need, please contact us and we would like to provide relevant information.
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