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Lidocaine Hydro-Chloride Injection

Basic Info

Model No.:  WI0030

Product Description

Model NO.: WI0030 Pharmaceutical Technology: Chemical Synthesis Trademark: aoshun Origin: China Mainland Type: Organic Chemicals Molecular Weight: 270.80 Specification: OEM/GMP               This product is a local anesthetic and antiarrhythmic drugs. Mainly used for anesthesia, epidural anesthesia, topical anesthesia (including for mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve conduction block. It can be used in patients with acute myocardial infarction premature ventricular contractions and ventricular tachycardia, it can be used for digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias. The product of supraventricular arrhythmias are usually ineffective.

Product:

Lidocaine Hydro-chloride Injection

Drug Category

Local anesthetics

Properties

colorless transparent liquid.

Storage

confined preservation.

CAS No.

73-78-9

Formula

C14H23ClN2O

Molecular Weight

270.80

Dosage


1. anesthesia:
(1) The usual dose for adults:
surface anesthesia: 2% -4% solution of a period not exceeding 100mg. When the injection time of not more than 4.5mg / kg  or per 7mg / kg (with a 1: 200,000 concentration of epinephrine).
caudal block for labor analgesia: with 1.0% solution to 200mg limit.
epidural: thoracolumbar 1.5% -2.0% solution, 250-300mg.
anesthesia or intravenous regional anesthesia: 0.25% -0.5% solution, 50-300mg.
peripheral nerve block: brachial plexus (unilateral) with 1.5% solution, 250-300mg; dentistry with a 2% solution, 20-100mg; intercostal nerve (each) with a 1% solution, 30mg, 300mg is limited; cervix next to the infiltration with 0.5% -1.0% solution, left and right side 100mg; paravertebral spinal nerve blocks (each) with 1.0% solution, 30-50mg, 300mg is limited; pudendal nerve with 0.5% -1.0% solution, left and right side 100mg.
sympathetic ganglion block: cervical stellate ganglion with 1.0% solution, 50mg; spinal anesthesia with 1.0% solution, 50-100mg.
time limit, without adrenal to 200mg (4mg / kg), epinephrine is 300-350mg (6mg / kg); intravenous regional block, maximum dose 4mg / kg; intravenous treatment with, for the first time at the beginning the amount of 1-2mg / kg, maximum dose 4mg / kg, adult intravenous 1mg per minute to be limited; repeated dosing intervals may not be less than 45-60 minutes.
(2) Pediatric usual dose: varies with the individual, the administration should not exceed a total 4.0-4.5mg / kg, commonly 0.25% -0.5% solution, special circumstances with 1.0% solution.
2. Anti-arrhythmic:
(1) amount used:
intravenous injection: 1-1.5mg / kg body weight (generally 50-100mg) as the first load of intravenous injection 2-3 minutes, repeated every 5 minutes after intravenous injection of 1-2 times if necessary, but always within one hour shall not exceed 300mg.
intravenous infusion: generally 5% dextrose injection dubbed 1-4mg / ml liquid infusion or administered by infusion pump. 1-4mg intravenous infusion rate can continue to be maintained at every minute after using load, or to 0.015-0.03mg per minute / kg body weight intravenously speed. The elderly, heart failure, cardiogenic shock, blood flow decreased liver or kidney dysfunction should reduce the dosage to 0.5-1mg per minute intravenous infusion. FDA to 0.1% solution intravenously, per hour of not more than 100mg.
(2) the maximum dose: intravenous injection within one hour maximum load of 4.5mg / kg body weight (or 300mg). The maximum maintenance dose per minute 4mg.

Adverse reactions


(1) It can affect the central nervous system, causing drowsiness, paresthesia, muscle tremors, convulsions, coma and respiratory depression and other adverse reactions.
(2) may cause hypotension and bradycardia. High plasma concentration, can cause slowing of atrial conduction velocity, atrioventricular block and inhibition of myocardial contractility and cardiac output.

Taboo symptoms


(1) local anesthetic allergies were banned;
(2) A - Sri Lanka's syndrome (acute cardiogenic cerebral ischemia syndrome), WPW syndrome, severe heart block (including sinoatrial, atrioventricular and intraventricular conduction delay) in patients with venous disabled.

NOTES


(1) to prevent intravascular, pay attention to diagnosis and treatment of anesthetic Bureau symptoms of poisoning.
(2) During the administration should pay attention to check blood pressure, ECG, and with rescue equipment; PR prolongation of ECG or QRS wave widened, have other arrhythmias or aggravate existing arrhythmias should be immediately discontinued.

The instructions


1. Pregnant women and lactating women use: This product is through the placenta and fetal protein binding than adults.
2. Pediatric Use: Newborns medication can cause poisoning, premature children than normal children long half-life (3.16 hours: 1.8 hours)
3. elderly patients: older drugs should be based on the needs and tolerance to adjust the dose,> 70 years old patient dose should be halved

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