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Cefuroxime Sodium for Injection

Basic Info

Model No.:  aoshun5632

Product Description

Model NO.: aoshun5632 Injection: 1g Certification: GMP, FDA                  Cefuroxime Sodium for Injection

Name: cefuroxime sodium for Injection Number: PI0015 Grade Standard: Medicine Grade Dosage Form: Injection Package: Brand: OEM/GMP Packaging Details: As usual,we also can make as your requirement. Place of Origin: China (Mainland) Port: any port of China
Cefuroxime Sodium for Injection


cefuroxime sodium for Injection

Basic information

This product is sterile powders cefuroxime sodium. Calculated as anhydrous. White or slightly yellow powder or crystalline powder; odorless, bitter taste. Shading, sealed and kept in a cool dry place.


The main ingredients cefuroxime sodium.

Chemical Name

(6R, 7R) -7- [2- furanyl (methoxyimino) acetamido] 3- carbamoyloxy oxo-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylate salts.



Molecular Weight



white to pale yellow powder or crystalline powder.


It can be used to cefuroxime sensitive bacteria caused by the following infections: 
1, respiratory tract infections: Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin resistant), Klebsiella spp., Staphylococcus aureus (penicillinase enzyme producing bacteria and non-penicillinase enzyme producing bacteria), purulent respiratory tract caused by Streptococcus and E. coli infections, such as acute and chronic bronchitis, bronchiectasis with infection, bacterial pneumonia, lung abscess, and pulmonary infection. 
2, ENT infections: otitis media, sinusitis, tonsillitis, pharyngitis. 
3, urinary tract infections: E. coli and Klebsiella urinary tract infections caused by bacteria, such as acute and chronic pyelonephritis, cystitis and asymptomatic bacteriuria. 
4, skin and soft tissue infections: Staphylococcus aureus (penicillinase enzyme producing bacteria and non-penicillinase enzyme producing bacteria), Streptococcus pyogenes, Escherichia coli, Klebsiella and caused intestinal bacteria of the genus skin and soft tissue infections, such as cellulitis, erysipelas, peritonitis and wound infections. 
5, sepsis: by Staphylococcus aureus (penicillinase enzyme producing bacteria and non-penicillinase enzyme producing bacteria), Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae (including ampicillin resistant) and Klebsiella caused by bacterial sepsis. 
6, meningitis: Streptococcus pneumoniae, Haemophilus influenzae (including ampicillin resistant), Neisseria meningitidis, and Staphylococcus aureus (penicillinase enzyme producing bacteria and non-penicillinase enzyme producing bacteria) caused by meningitis. 
7, gonorrhea: from simple (uncomplicated) Neisseria gonorrhoeae (penicillinase enzyme producing bacteria and non-penicillinase enzyme producing bacteria) caused by gonorrhea and there are complications, especially for not penicillin treatment. 
8, bone and joint infections: bone and joint infections caused by Staphylococcus aureus (penicillinase enzyme producing bacteria and non-penicillinase enzyme producing bacteria) caused. This product can still be used before surgery or surgery to prevent the growth of sensitive pathogens, reduce intraoperative and postoperative infection caused by pollution. Such as the abdomen and pelvis orthopedic surgery, heart, lung, esophageal and vascular surgery, total joint replacement surgery to prevent infection.


It can be deep intramuscular injection, or intravenous injection or infusion. 
1. intramuscular administration of the product per 0.25g dissolved in 3ml of sterile water for injection with 1.0ml of sterile injectable dissolved in water or 0.75g, was after the slow shake suspension only deep intramuscular injection. Before intramuscular injection, it is necessary Withdrawing without blood before injection. 
2. Intravenous: 0.25g least with 2.0ml sterile water for injection were dissolved, 0.75g least with 6.0ml sterile water for injection were dissolved, 1.5g least with 15ml sterile water for injection to dissolve, and then shake slow intravenous injection, can also be Join intravenous drip tube. 
3. intravenous infusion: 1.5g cefuroxime may be added to at least 50ml commonly used intravenous fluids, not compatible with the use of aminoglycoside antibiotics. 
4. This product is commonly used in adults for each 0.75g, administered every 8 hours, 5-10 days of treatment for life-threatening infection or rare serious infections caused by susceptible strains, each time increased to 1.5g, every 3 times a day; if necessary, the interval may be increased to once every six hours, the daily total of 3-6g. For bacterial meningitis, the dose every 8 hours should not exceed 3.0g. For uncomplicated gonorrhea intramuscular injection of a single dose of 1.5g, divided note hips on both sides. 
5. Prevention of surgical infections: 0.5 to 1.5 hours before surgery intravenous injection of this product 1.5g, if the operation time is too long, then every 8 hours intravenous or intramuscular 0.75g dose. If it is open heart surgery, it should be with the introduction, intravenous anesthetic 1.5g; later administered once every 12 hours, a total dose of 6g. 
6.3 months or more children, the daily per kilogram of body weight 50-100mg, 3-4 doses. Severe infections, daily per kilogram of body weight amount of not less than 0.1g, but can not exceed the maximum adult dose. Bone and joint infections, daily per kilogram of body weight 0.15g (no more than the highest dose used by adults), three doses. Meningitis patients per day per kilogram of body weight 0.2-0.24g, 3-4 doses. 
7. Renal dysfunction, renal impairment should be based on the degree to adjust the usage and dosage, the recommended adjustment in the table below. 
8. renal insufficiency in children, making adjustments should also refer to the table below. 
9. creatinine clearance (ml / min) dose interval > 20 0.75-1.5g per 8h 10-20 0.75g per 12h <10 0.75g every 24h 
10. For dialysis patients, at the end of dialysis, should then be given a single dose of 0.75g.

Adverse reactions

The product is well tolerated, common adverse reactions are as follows: 
1, local reaction: If intramuscular injection site pain, thrombosis, phlebitis. 
2, gastrointestinal reactions: such as diarrhea, nausea, pseudomembranous colitis. 
3, allergic reactions: common skin rash, pruritus, urticaria. Occasionally allergy, drug fever, erythema multiforme, interstitial nephritis, toxic epidermal exfoliative dermatitis, Stevens Johnson syndrome. 
4. Blood: the visible hemoglobin and hematocrit decrease, transient eosinophilia syndrome, transient neutropenia, thrombocytopenia and leukopenia psychosis, and occasionally thrombocytopenia. 
5, liver function: Visibility ALT, AST, alkaline phosphatase, lactate dehydrogenase and a transient increase in serum bilirubin. 
6, other: still see vomiting, abdominal pain, conjunctivitis, vaginitis (vaginal candidiasis disease), abnormal liver function (including cholestasis), aplastic anemia, hemolytic anemia, hemorrhage, causing seizures, prothrombin time prolonged pancytopenia, agranulocytosis psychosis. Taboo: cephalosporins or cephamycins drug allergy FDA ban.


1, the product with penicillin cross allergic reactions. Who are allergic to penicillin drugs, be careful using this product. Penicillin anaphylactic shock, should not re-elect the FDA. 
2, when using this product should pay attention to monitoring of renal function, especially in patients receiving high-dose intensive. 
3, renal dysfunction, the daily dose should be reduced. Diuretics or patients with application of potent aminoglycoside antibiotics should pay particular attention, because the combination therapy had cause renal damage were reported. For these patients, renal function monitoring is preferably carried out. 
4, this product can cause pseudomembranous colitis, have a history of gastrointestinal disease, particularly ulcerative colitis, colitis or antibiotic-associated colitis patients should be vigilant. After the diagnosis of pseudomembranous colitis is established, it should be given appropriate treatment. Withdrawal can be mild, moderate and severe should be given fluids, electrolytes, protein supplement, and should be chosen for Clostridium effective antibiotic drug therapy. 
5, the FDA reported small number of children with mild to moderate hearing loss occurs. 
6, compatibility and stability: Intramuscular injection: sterile water for injection preparation time, the product suspension at room temperature for 24 hours, 5 ºC refrigerator to save 48 hours to remain active. After this period, any unused solution should be discarded. Intravenous: The sterile injectable preparation using water, 750mg, 1.5g formulated solution after 24 hours at room temperature, 5 ºC refrigerator for 48 hours to remain active. This product can remain compatible within 24 hours at room temperature with the following solution: heparin (10-50u / ml), potassium chloride (10-40mEq / l), 0.9% sodium chloride. This product is 750mg and 1.5g, with 50ml or 100ml5% glucose injection, 0.9% sodium chloride injection, 0.45% sodium chloride injection diluted, can be stored at room temperature for 24 hours, refrigerator stored for 7 days. 
7, interfere with the diagnosis: It can interfere with direct Coombs test results show positive responses to this phenomenon can interfere with the blood of the cross; there will be time for Benedict or Fehling test test or urine dipstick test Clintest tabets false positive reactions, but the enzyme test method is not a false positive. When to check blood sugar, such as false negative results may occur with iron cyanate method, cefuroxime sodium does not interfere with urine and blood inosine value with an alkaline picric acid method.

Pregnant and lactating women

Pregnant women should be weighed. This product can be secreted into the milk, lactation.

Pediatric Use

It has been reported neonatal cephalosporin stored role, safety and efficacy has not been established for children less than three months, therefore, not recommended.

Geriatric Use

There is currently a lack of detailed research data. Elderly kidney dysfunction, dosage should be adjusted.

I hope you will contact me if you have any further question and concerns.Thankyou.

Best regards
Zhuhai Aoshun Medicine CO.,LTD found in 1988.We have got GSP&GMP approval.Own reputation at the past more than twenty years.We will supply excellent product and service.

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